Polymeric Gadolinium Chelate Magnetic Resonance Imaging Contrast Agents: Design, Synthesis, and Properties
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- 作者：David L. Ladd ; Robert Hollister ; Xin Peng ; Donna Wei ; Gang Wu ; Daniel Delecki ; Robert A. Snow ; John L. Toner ; Kenneth Kellar ; Jennifer Eck ; Vinay C. Desai ; Gemma Raymond ; Lewis B. Kinter ; Terry S. Des
- 刊名：Bioconjugate Chemistry
- 出版年：1999
- 出版时间：May 1999
- 年：1999
- 卷：10
- 期：3
- 页码：361 - 370
- 全文大小：400K
- 年卷期：v.10,no.3(May 1999)
- ISSN：1520-4812
文摘
We have synthesized and evaluated five series of polymeric gadolinium chelates which are of interestas potential MRI blood pool contrast agents. The polymers were designed so that important physicalproperties including molecular weight, relaxivity, metal content, viscosity, and chelate stability couldbe varied. We have shown that, by selecting polymers of the appropriate MW, extended blood poolretention can be achieved. In addition, relaxivity can be manipulated by changing the polymer rigidity,metal content affected by monomer selection, viscosity by polymer shape, and chelate stability bychelator selection.