Synthesis of Catechins via Thiourea/AuCl3-Catalyzed Cycloalkylation of Aryl Epoxides

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• 作者：Yongxiang Liu ; Xiben Li ; Guang Lin ; Zheng Xiang ; Jing Xiang ; Mingzhe Zhao ; Jiahua Chen ; Zhen Yang
• 刊名：Journal of Organic Chemistry
• 出版年：2008
• 出版时间：June 20, 2008
• 年：2008
• 卷：73
• 期：12
• 页码：4625 - 4629
• 全文大小：733K
• 年卷期：v.73,no.12(June 20, 2008)
• ISSN：1520-6904

文摘

A diversity-oriented approach for the synthesis of structurally diverse catechins was achieved in good yields via thiourea/AuCl₃/AgOTf-catalyzed annulations of aryl epoxides under mild conditions. This new protocol provides a highly efficient entry to a library of catechins-derived natural products, notably anti-HIV agent 8-C-ascorbyl-(−)-epigallocatechin.