Coibamide A, a Potent Antiproliferative Cyclic Depsipeptide from the Panamanian Marine Cyanobacterium Leptolyngbya sp.

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• 作者：Rebecca A. Medina ; Douglas E. Goeger ; Patrice Hills ; Susan L. Mooberry ; Nelson Huang ; Luz I. Romero ; Eduardo Ortega-Barrí ; a ; William H. Gerwick ; Kerry L. McPhail
• 刊名：Journal of the American Chemical Society
• 出版年：2008
• 出版时间：May 21, 2008
• 年：2008
• 卷：130
• 期：20
• 页码：6324 - 6325
• 全文大小：129K
• 年卷期：v.130,no.20(May 21, 2008)
• ISSN：1520-5126

文摘

Coibamide A (1) is a new, potent antiproliferative depsipeptide which was isolated from a marine Leptolyngbya cyanobacterium collected from the Coiba National Park, Panama. The planar structure of 1 was elucidated by a combination of NMR spectroscopy and mass spectrometry. Exhaustive 1D and 2D NMR spectroscopy included natural abundance ¹⁵N and variable temperature experiments; mass spectrometry included TOF-ESI-MSⁿ and FT-MSⁿ experiments. Chemical degradation followed by chiral HPLC− and GC−MS analyses was used to assign the absolute configuration of 1. This highly methylated cyclized depsipeptide exhibited an unprecedented selectivity profile in the NCI 60 cancer cell line panel and appears to act via a novel mechanism.