LAT Transport Inhibitors from Pittosporum venulosum Identified by NMR Fingerprint Analysis

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• 作者：Tanja Grkovic ; Rebecca H. Pouwer ; Qian Wang ; Gordon P. Guymer ; Jeff Holst ; Ronald J. Quinn
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：June 26, 2015
• 年：2015
• 卷：78
• 期：6
• 页码：1215-1220
• 全文大小：321K
• ISSN：1520-6025

文摘

¹H NMR fingerprints were used as the guiding principle for the isolation of minor compounds related to the l-type amino acid transporter inhibitors venulosides A (1) and B (2). Two new monoterpene glycosides, namely, venulosides C (3) and D (4), were isolated from a Queensland collection of the plant Pittosporum venulosum. Compounds 3 and 4 were found to inhibit l-leucine transport in LNCaP cells with IC₅₀ values of 11.47 and 39.73 渭M, respectively. The venulosides are the first reported natural product inhibitors of leucine transport in prostate cancer cells, and the isolation of the minor compounds provides some early SAR information.