Antinociceptive Properties of Bergenin

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• 作者：Cristiane Metzker de Oliveira ; Fabiana Regina Nonato ; Fl谩via Oliveira de Lima ; Ricardo David Couto ; Juceni P. David ; Jorge M. David ; Milena Botelho Pereira Soares ; Cristiane Flora Villarreal
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：October 28, 2011
• 年：2011
• 卷：74
• 期：10
• 页码：2062-2068
• 全文大小：828K
• 年卷期：v.74,no.10(October 28, 2011)
• ISSN：1520-6025

文摘

Bergenin (1) is a C-glucoside of 4-O-methylgallic acid with known antiarthritic activity attributed to modulation of cytokine production. The present study was undertaken to evaluate whether 1 has antinociceptive properties in models of inflammatory pain and to investigate its possible mechanisms of action. Pretreatment with 1 (12.5鈥?00 mg/kg, ip) produced a dose-related inhibition of acetic acid-induced writhing in mice. Furthermore, treatment with 1 (50 and 100 mg/kg) inhibited both the early and late phases in a formalin test. In addition, 1 (50 and 100 mg/kg, ip) inhibited mechanical hyperalgesia, edema, and paw production of hyperalgesic cytokines (TNF-伪 and IL-1尾) induced by complete Freund鈥檚 adjuvant. However, the local production of IL-10, an anti-inflammatory cytokine, was not altered by 1 (100 mg/kg, ip). Treatment with 1 produced a similar profile of antinociception in wild-type and IL-10-deficient mice. Mice treated with 1 did not show any motor performance alterations or apparent systemic toxicity. The results presented herein demonstrate that bergenin has consistent antinociceptive and anti-inflammatory properties, acting by the inhibition of IL-1尾 and TNF-伪 production, and suggest its potential for the control of inflammatory pain.