Particle Size Control in Batch Crystallization of Pyrazinamide on Different Scales

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• 作者：Zai-Qun YuAlvin Yeoh ; Pui Shan Chow ; Reginald B. H. Tan
• 刊名：Organic Process Research & Development
• 出版年：2016
• 出版时间：December 16, 2016
• 年：2016
• 卷：20
• 期：12
• 页码：2100-2107
• 全文大小：420K
• ISSN：1520-586X

文摘

A methodology to achieve consistent particle size in seeded batch crystallization on two scales (0.5 and 10 L) was demonstrated using pyrazinamide as a model compound. An empirical process model was established from a Design of Experiment study on the 500 mL scale and subsequently verified by correlating Db>50b> of the crystals with stirrer speed, seed size, and seed loading. Experiments on the 10 L scale showed that the criterion of equivalent impeller tip speed produced a larger Db>50b> than that of equivalent input energy. The process model derived from the 0.5 L scale was demonstrated to work well for process parameter adjustment to obtain the target product size on the 10 L scale. Some practical issues in crystallization development are discussed.