Switching Invariant Natural Killer T (iNKT) Cell Response from Anticancerous to Anti-Inflammatory Effect: Molecular Bases
详细信息 查看全文
- 作者：Xavier Laurent ; Benjamin Bertin ; Nicolas Renault ; Amaury Farce ; Silvia Speca ; Oph茅lie Milhomme ; R茅gis Millet ; Pierre Desreumaux ; Eric H茅non ; Philippe Chavatte
- 刊名：Journal of Medicinal Chemistry
- 出版年：2014
- 出版时间：July 10, 2014
- 年：2014
- 卷：57
- 期：13
- 页码：5489-5508
- 全文大小：1047K
- ISSN：1520-4804
文摘
Since the discovery in 1995 of 伪-galactosylceramide 1 (伪-GalCer), also known as KRN7000,1 hundreds of compounds have been synthesized in order to activate invariant natural killer T (iNKT) cells. Such keen interest for this lymphocyte cell type is due to its ability to produce different cytokines that bias the immune response toward a Th1 or Th2 profile. Thus, an understanding of the immune polarization mechanism via iNKT activation may pave the way toward new therapeutics in various domains including cancer and infectious and autoimmune diseases. In this review, we propose an up-to-date analysis of iNKT activators associated with a structure鈥揳ctivity relationship (SAR) study aimed at complementing available reviews by highlighting molecular bases for a selective immune response.