Suncheonosides A鈥揇, Benzothioate Glycosides from a Marine-Derived Streptomyces sp.

详细信息    查看全文

• 作者：Bora Shin ; Seyeon Ahn ; Minsoo Noh ; Jongheon Shin ; Dong-Chan Oh
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：June 26, 2015
• 年：2015
• 卷：78
• 期：6
• 页码：1390-1396
• 全文大小：317K
• ISSN：1520-6025

文摘

A marine-derived Streptomyces strain, SSC21, was isolated from the sediment of Suncheon Bay, Republic of Korea. Chemical analysis of the bacterial strain resulted in the isolation of four new metabolites, suncheonosides A鈥揇 (1鈥?, respectively), each bearing a sulfur atom. The planar structures of the suncheonosides were identified as hexasubstituted benzothioate glycosides by combined spectroscopic analyses. Analysis of the configuration of the sugar moieties based on ROESY nuclear magnetic resonance correlations, one-bond ¹H鈥?sup>13C coupling constant analysis, and chemical derivatizations indicated that the suncheonosides incorporate only l-rhamnose. Suncheonosides A, B, and D promoted adiponectin production in a concentration-dependent manner during adipogenesis in human mesenchymal stem cells, suggesting antidiabetic potential.