Balgacyclamides, Antiplasmodial Heterocyclic Peptides from Microcystis aeruguinosa EAWAG 251

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• 作者：Cyril Portmann ; Simon Sieber ; Silvan Wirthensohn ; Judith F. Blom ; Laeticia Da Silva ; Emilie Baudat ; Marcel Kaiser ; Reto Brun ; Karl Gademann
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：March 28, 2014
• 年：2014
• 卷：77
• 期：3
• 页码：557-562
• 全文大小：278K
• 年卷期：v.77,no.3(March 28, 2014)
• ISSN：1520-6025

文摘

The isolation and structural characterization of three new heterocyclic and macrocyclic peptides, balgacyclamides A鈥揅, from Microcystis aeruginosa EAWAG 251 are reported. The constitutions were determined by 2D-NMR methods and mass spectrometry, and the configurations were assigned after ozonolysis and hydrolysis by HPLC-MS methods using Marfey鈥檚 method as well as GC-MS using authentic standards. Balgacyclamides A and B were active against Plasmodium falciparum K1 in the low micromolar range, while displaying low toxicity to rat myoblasts.