A Chemo-Enzymatic Route to Enantiomerically Pure Cyclic Tertiary Amines

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• 作者：Colin J. Dunsmore ; Reuben Carr ; Toni Fleming ; and Nicholas J. Turner
• 刊名：Journal of the American Chemical Society
• 出版年：2006
• 出版时间：February 22, 2006
• 年：2006
• 卷：128
• 期：7
• 页码：2224 - 2225
• 全文大小：42K
• 年卷期：v.128,no.7(February 22, 2006)
• ISSN：1520-5126

文摘

Deracemization of racemic chiral tertiary amines has been achieved by combination of an enantioselective amine oxidase, obtained through directed evolution, and ammonia borane in a one-pot process.