文摘
An unusual isomer of domoic acid (1), isodomoic acid C (2), has been found in New Zealandshellfish contaminated by amnesic shellfish poisoning (ASP) toxins and was shown to beproduced by a local strain of the pennate diatom Pseudo-nitzschia australis. A bulk culture ofthis strain was used to isolate 2. The structure was determined from spectroscopic data andwas shown to correspond to that of 2 from a Japanese red seaweed, the only other reportedoccurrence of this compound. The affinity of 2 for GluR6 glutamate receptors was 240-foldlower than for 1, indicating low neurotoxic potential.