Isodomoic Acid C, an Unusual Amnesic Shellfish Poisoning Toxin from Pseudo-nitzschia australis
详细信息 查看全文
- 作者：Patrick T. Holland ; Andrew I. Selwood ; Douglas O. Mountfort ; Alistair L. Wilkins ; Paul McNabb ; Lesley L. Rhodes ; Gregory J. Doucette ; Christina M. Mikulski ; and Kristen L. King
- 刊名：Chemical Research in Toxicology
- 出版年：2005
- 出版时间：May 2005
- 年：2005
- 卷：18
- 期：5
- 页码：814 - 816
- 全文大小：71K
- 年卷期：v.18,no.5(May 2005)
- ISSN：1520-5010
文摘
An unusual isomer of domoic acid (1), isodomoic acid C (2), has been found in New Zealandshellfish contaminated by amnesic shellfish poisoning (ASP) toxins and was shown to beproduced by a local strain of the pennate diatom Pseudo-nitzschia australis. A bulk culture ofthis strain was used to isolate 2. The structure was determined from spectroscopic data andwas shown to correspond to that of 2 from a Japanese red seaweed, the only other reportedoccurrence of this compound. The affinity of 2 for GluR6 glutamate receptors was 240-foldlower than for 1, indicating low neurotoxic potential.