Rapid Diagnosis of Tuberculosis from Analysis of Urine Volatile Organic Compounds
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- 作者：Sung H. Lim ; Raymond Martino ; Victoria Anikst ; Zeyu Xu ; Samantha Mix ; Robert Benjamin ; Herbert Schub ; Michael Eiden ; Paul A. Rhodes ; Niaz Banaei
- 刊名：ACS Sensor
- 出版年：2016
- 出版时间：July 22, 2016
- 年：2016
- 卷：1
- 期：7
- 页码：852-856
- 全文大小：402K
- ISSN：2379-3694
文摘
The World Health Organization has called for simple, sensitive, and nonsputum diagnostics for tuberculosis. We report development of a urine tuberculosis test using a colorimetric sensor array (CSA). The sensor comprising 73 different indicators captures high-dimensional, spatiotemporal signatures of volatile chemicals emitted by human urine samples. The sensor responses to 63 urine samples collected from 22 tuberculosis cases and 41 symptomatic controls were measured under 5 different urine test conditions. Basified testing condition yielded the best accuracy with 85.5% sensitivity and 79.5% specificity. The CSA urine assay offers desired features needed for tuberculosis diagnosis in endemic settings.