Cerium(IV) Ammonium Nitrate Is an Excellent, General Catalyst for the Friedlnder and Friedlnder−Borsche Quinoline Syntheses: Very Efficient Access to the Antitumor Alkaloid Luotonin A

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• 作者：Vellaisamy Sridharan ; Pascual Ribelles ; M^a Teresa Ramos ; J. Carlos Menndez
• 刊名：Journal of Organic Chemistry
• 出版年：2009
• 出版时间：August 7, 2009
• 年：2009
• 卷：74
• 期：15
• 页码：5715-5718
• 全文大小：732K
• 年卷期：v.74,no.15(August 7, 2009)
• ISSN：1520-6904

文摘

The use of cerium(IV) ammonium nitrate as a catalyst of the Friedlnder reaction allows the synthesis of polysubstituted quinoline derivatives in excellent yields, avoiding the traditional harshly basic or acidic conditions. Unlike most other previously known reagents, CAN allows double condensations and is also an excellent catalyst for the Borsche variation of the Friedlnder reaction, which has been applied to the very efficient synthesis of the antitumor alkaloid luotonin A.