Antimalarial Activity of Physalins B, D, F, and G
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- 作者：Matheus S. S谩 ; Maria N. de Menezes ; Antoniana U. Krettli ; Ivone M. Ribeiro ; Therezinha C. B. Tomassini ; Ricardo Ribeiro dos Santos ; Walter F de Azevedo ; Jr. ; Milena B. P. Soares
- 刊名：Journal of Natural Products
- 出版年：2011
- 出版时间：October 28, 2011
- 年：2011
- 卷：74
- 期：10
- 页码：2269-2272
- 全文大小：236K
- 年卷期：v.74,no.10(October 28, 2011)
- ISSN：1520-6025
文摘
The antimalarial activities of physalins B, D, F, and G (1鈥?b>4), isolated from Physalis angulata, were investigated. In silico analysis using the similarity ensemble approach (SEA) database predicted the antimalarial activity of each of these compounds, which were shown using an in vitro assay against Plasmodium falciparum. However, treatment of P. berghei-infected mice with 3 increased parasitemia levels and mortality, whereas treatment with 2 was protective, causing a parasitemia reduction and a delay in mortality in P. berghei-infected mice. The exacerbation of in vivo infection by treatment with 3 is probably due to its potent immunosuppressive activity, which is not evident for 2.