Lariat Ether Receptor Systems Show Experimental Evidence for Alkali Metal Cation- Interactions
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- 作者：George W. Gokel ; Leonard J. Barbour ; Riccardo Ferdani ; and Jiaxin Hu
- 刊名：Accounts of Chemical Research
- 出版年：2002
- 出版时间：October 2002
- 年：2002
- 卷：35
- 期：10
- 页码：878 - 886
- 全文大小：667K
- 年卷期：v.35,no.10(October 2002)
- ISSN：1520-4898
文摘
Cation-
interactions occur between cations and electron-richspecies such as double bonds, triple bonds, and arenes. The-electron system may be neutral or anionic, but the latter are lessrelevant to biology, at least so far as is currently known. Amongthe 20 essential amino acids, there are four aromatic residues.These are benzene, phenol, indole, and imidazole, on the sidechains of phenylalanine, tyrosine, tryptophan, and histidine,respectively. Of these, imidazole is expected to be a 
-donor, andbenzene, phenol, and indole are antipicated to serve as -donors.Sodium and potassium are the most abundant cations in livingsystems. This Account describes an experimental system that hasbeen developed to probe, especially by X-ray crystallography, theinteractions that occur between Na+ or K+ and the neutral arenesof particular biological significance.
interactions occur between cations and electron-richspecies such as double bonds, triple bonds, and arenes. The-electron system may be neutral or anionic, but the latter are lessrelevant to biology, at least so far as is currently known. Amongthe 20 essential amino acids, there are four aromatic residues.These are benzene, phenol, indole, and imidazole, on the sidechains of phenylalanine, tyrosine, tryptophan, and histidine,respectively. Of these, imidazole is expected to be a -donor, andbenzene, phenol, and indole are antipicated to serve as -donors.Sodium and potassium are the most abundant cations in livingsystems. This Account describes an experimental system that hasbeen developed to probe, especially by X-ray crystallography, theinteractions that occur between Na+ or K+ and the neutral arenesof particular biological significance.