Water-Based Synthesis of Ultrasmall PEGylated Gold鈥揝ilica Core鈥揝hell Nanoparticles with Long-Term Stability

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• 作者：Yao Sun ; Hiroaki Sai ; Frederick von Stein ; Mark Riccio ; Ulrich Wiesner
• 刊名：Chemistry of Materials
• 出版年：2014
• 出版时间：September 23, 2014
• 年：2014
• 卷：26
• 期：18
• 页码：5201-5207
• 全文大小：543K
• ISSN：1520-5002

文摘

Ultrasmall gold nanoparticles have attracted great interest in biomedical applications due to the intrinsic properties of gold nanoparticles and their potential renal clearance capability. We present a synthetic method for a type of sub-10 nm core鈥搒hell nanoparticle composed of an ultrasmall gold core, a thin silica shell, and a polyethylene glycol (PEG) outer layer. The thin silica shell is crucial in terms of maintaining colloidal stability of the nanoparticles. The PEG layer provides a neutral surface as well as steric stabilization. The core鈥搒hell nanoparticles show long-term stability for nearly a year in both water and PBS buffer solution even when stored at room temperature. The nanoparticle suspensions further exhibit high contrast in a microscale computed tomography scanner. This study suggests that these ultrasmall gold鈥搒ilica core鈥搒hell nanoparticles can be used as a promising platform for future biomedical applications in imaging, diagnostics, and theranostics.