Icacinlactone H and Icacintrichantholide from the Tuber of Icacina trichantha
详细信息 查看全文
- 作者：Ming Zhao ; Monday M. Onakpa ; Bernard D. Santarsiero ; Xiao-Jun Huang ; Xiao-Qi Zhang ; Jia Chen ; Jian-Jun Cheng ; Richard Longnecker ; Chun-Tao Che
- 刊名：Organic Letters
- 出版年：2015
- 出版时间：August 7, 2015
- 年：2015
- 卷：17
- 期：15
- 页码：3834-3837
- 全文大小：272K
- ISSN：1523-7052
文摘
The 17-norpimarane diterpene is a small group of natural products. A new member, icacinlactone H (1), and a new rearranged 17-norpimarane with an unprecedented carbon skeleton, icacintrichantholide (2), were isolated from Icacina trichantha. Their structures including the absolute configuration were elucidated by spectroscopic analysis, single-crystal X-ray diffraction, and electronic circular dichroism analysis. A plausible biogenetic pathway for 1 and 2 is proposed. Both 1 and 2 showed no significant activity against herpes simplex viruses HSV-1 and HSV-2 as well as the Epstein鈥揃arr virus at 50 渭M.