A Dual Sensor Spin Trap for Use with EPR Spectroscopy

详细信息    查看全文

• 作者：Stuart T. Caldwell ; Caroline Quin ; Ruth Edge ; Richard C. Hartley
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：August 30, 2007
• 年：2007
• 卷：9
• 期：18
• 页码：3499 - 3502
• 全文大小：98K
• 年卷期：v.9,no.18(August 30, 2007)
• ISSN：1523-7052

文摘

Redox active metal ions, carbon-centered radicals, and oxygen-centered radicals are important to oxidative stress. A radical detector combininga nitrone spin trap, a phenol, and a cyclopropane radical clocklike unit was prepared and used with EPR spectroscopy to detect and distinguishbetween hydroxyl radicals, methyl radicals, and iron(III) ions. Iron(III) reacts with the phenol unit inducing opening of the cyclopropane ringand cyclization to generate a stable nitroxyl radical.