Differentially Addressable Cavities within Metal鈥揙rganic Cage-Cross-Linked Polymeric Hydrogels

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• 作者：Jonathan A. Foster ; Richard M. Parker ; Ana M. Belenguer ; Norifumi Kishi ; Sam Sutton ; Chris Abell ; Jonathan R. Nitschke
• 刊名：Journal of the American Chemical Society
• 出版年：2015
• 出版时间：August 5, 2015
• 年：2015
• 卷：137
• 期：30
• 页码：9722-9729
• 全文大小：532K
• ISSN：1520-5126

文摘

Here we report a new class of hydrogels formed by polymers that are cross-linked through subcomponent self-assembled metal鈥搊rganic cages. Selective encapsulation of guest molecules within the cages creates two distinct internal phases within the hydrogel, which allows for contrasting release profiles of related molecules depending on their aptitude for encapsulation within the cages. The hydrogels were fabricated into microparticles via a droplet-based microfluidic approach and proved responsive to a variety of stimuli, including acid and competing amine or aldehyde subcomponents, allowing for the triggered release of cargo.