文摘
A series of nonsteroidal 鈥渄issociated鈥?glucocorticoid receptor agonists was optimized for drug-like properties such as cytochrome P450 inhibition, metabolic stability, aqueous solubility, and hERG ion channel inhibition. This effort culminated in the identification of the clinical candidate compound (R)-39.
Keywords:
Glucocorticoid mimetics; nonsteroidal glucocorticoids; glucocorticoid-induced osteoporosis; azaindoles; anti-inflammatory agents; drug-like properties