Synthesis and Characterization of 12-Pyridinium Derivatives of the [closo-1-CB11H12]鈭?/sup> Anion
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- 作者：Jacek Pecyna ; Bryan Ringstrand ; S艂awomir Domaga艂a ; Piotr Kaszy艅ski ; Krzysztof Wo藕niak
- 刊名：Inorganic Chemistry
- 出版年：2014
- 出版时间：December 1, 2014
- 年：2014
- 卷：53
- 期：23
- 页码：12617-12626
- 全文大小：489K
- ISSN：1520-510X
文摘
Diazotization of [closo-1-CB11H10-1-R-12-NH2]鈭?/sup>[NMe4]+ (4[NMe4]) in neat 4-methoxypyridine leads to 12-(4-methoxypyridinium) zwitterions [closo-1-CB11H10-1-R-12-(4-MeOC5H4N)] (2) in 鈭?0% yield. Demethylation of 2 with LiCl in dimethylformamide provides access to 12-pyridones 5[NMe4], which can be O-alkylated with alkyl triflates giving 12-(4-alkoxypyridinium) zwitterions, such as 1. This three-step process is more efficient than direct diazotization of amine 4[NMe4] in neat higher 4-alkoxypyridine. The new method was demonstrated for the synthesis of [closo-1-CB11H10-1-C5H11-12-(4-C7H15OC5H4N)] (1c), which exhibits a smectic A phase. Molecular and electronic structures of 4-methoxypyridinium zwitterion 2b and its C(1) isomer [closo-1-CB11H11-1-(4-MeOC5H4N)] (3b) were investigated by single-crystal X-ray diffraction and spectroscopic methods, respectively, and the experimental results were compared to those obtained with density functional theory methods. Lastly, the mechanism for formation of zwitterions 2 was investigated computationally revealing low energy for dediazoniation of the [closo-1-CB11H10-1-R-12-N2] (14) intermediate (螖G298 鈮?25 kcal/mol) to form boronium ylide 15, with weak dependence on substituent R. Dinitrogen derivative 14c was observed by 11B NMR spectroscopy.