Inve
stigation of novel biomaterial
s for bone regeneration i
s ba
sed on the development of
scaffold
s that exhibit bone-bonding ability, biocompatibility, and
sufficient mechanical
strength. In thi
s study, u
sing novel poly (蔚-caprolactone)/bioactive gla
ss (PCL/BG) hybrid
s with different organic/inorganic ratio
s, the effect
s of BG content
s on the in vitro bone-like hydroxyapatite (HA) formation, mechanical propertie
s, and biocompatibility were inve
stigated. Rapid precipitation of HA on the PCL/BG hybrid
surface
s were ob
served after incubating in
simulated body fluid (SBF) for only 6 h, a
s confirmed by
scanning electron micro
scopy (SEM), energy di
sper
sive X-ray
spectro
scopy (EDX), Fourier-tran
sform infrared
spectro
scopy (FTIR), and inductively coupled pla
sma atomic emi
ssion
spectro
scopy (ICPS). The ICPS elemental analy
si
s re
sult
s were further analyzed in term
s of the Ca<
sup>2+
sup> and PO<
sub>4
sub><
sup>3鈥?/
sup> which were con
sumed to form the apatite layer. The re
sult
s revealed that the rate and total amount of HA depo
sition decrea
sed with an increa
se in PCL content. The compre
ssive modulu
s and
strength of the PCL/BG hybrid
s increa
sed with the decrea
se in PCL content. The highe
st value
s were achieved at the lowe
st PCL content (10 wt %) and were around, 90 MPa and 1.4 GPa, re
spectively. To evaluate the cytotoxicity of PCL/BG bioactive hybrid
s, MC3T3-E1 o
steobla
st-like cell
s were cultured for up to 72 h. Our data indicated that wherea
s initial cell attachment wa
s marginally lower than the control ti
ssue culture poly
styrene (TCPS)
surface, the hybrid material
s promoted cell growth in a time-dependent manner. Cell viability within the different PCL/BG hybrid
sample
s appeared to be influenced by compo
sitional difference
s whereby higher PCL content
s correlated with
slight reduction in cell viability. Taken together, thi
s study add
s important new information to our knowledge on hydroxyapatite formation, mechanical propertie
s, and cytotoxic effect
s of PCL/BG hybrid
s prepared by the
sol鈥揼el proce
ss u
sing a tertiary gla
ss compo
sition and may have con
siderable potential for bone ti
ssue regeneration application
s.
Keywords:
s" href="http://pubs.acs.org/action/doSearch?action=search&searchText=bone+regeneration&qsSearchArea=searchText">bone regeneration; s" href="http://pubs.acs.org/action/doSearch?action=search&searchText=organic%E2%88%92inorganic+hybrids&qsSearchArea=searchText">organic鈭抜norganic hybrids; s" href="http://pubs.acs.org/action/doSearch?action=search&searchText=poly+%5C%28%CE%B5%5C-caprolactone%5C%29&qsSearchArea=searchText">poly (蔚-caprolactone); s" href="http://pubs.acs.org/action/doSearch?action=search&searchText=bioactive+glass&qsSearchArea=searchText">bioactive glass; s" href="http://pubs.acs.org/action/doSearch?action=search&searchText=bioactivity&qsSearchArea=searchText">bioactivity