Synthesis of a Parkinson’s Disease Treatment Drug, the R,R-Tartrate Salt of R-Rasagiline: A Three Week Introductory Organic Chemistry Lab Sequence

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• 作者：Noberto Aguilar ; Billy Garcia ; Mark Cunningham ; Samuel David
• 刊名：Journal of Chemical Education
• 出版年：2016
• 出版时间：May 10, 2016
• 年：2016
• 卷：93
• 期：5
• 页码：937-940
• 全文大小：240K
• 年卷期：0
• ISSN：1938-1328

文摘

A synthesis of the R,R-tartrate salt of the popular anti-Parkinson’s drug R-rasagiline (Azilect) was adapted to introduce the organic laboratory student to a medically relevant synthesis. It makes use of concepts found in the undergraduate organic chemistry curriculum, appropriately fits into three approximately 4 h lab periods, and utilizes readily available equipment and inexpensive commercially available chemicals.