Cadinane-Type Sesquiterpenoids from Heterotheca inuloides: Absolute Configuration and Anti-inflammatory Activity

详细信息    查看全文

• 作者：Ver贸nica Egas ; Rub茅n A. Toscano ; Edelmira Linares ; Robert Bye ; Francisco J. Espinosa-Garc铆a ; Guillermo Delgado
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：November 25, 2015
• 年：2015
• 卷：78
• 期：11
• 页码：2634-2641
• 全文大小：365K
• ISSN：1520-6025

文摘

Eight cadinane-type sesquiterpenoids (1鈥?b>8) together with some triterpenoids, flavonoids, and sterols were isolated from the aerial parts of Heterotheca inuloides. The structures of the new compounds (1鈥?b>4) were elucidated on the basis of extensive 1D and 2D NMR spectroscopic data analysis. The structures of the new (1鈥?b>3) and the known (5鈥?b>7) sesquiterpenoids were confirmed by X-ray crystallography. The absolute configurations of metabolites 2鈥?b>5 were determined by comparing their experimental and calculated electronic circular dichroism spectra and confirmed via refinement of the Flack parameter using anomalous X-ray scattering from the oxygen atoms and chemical correlation methods. The sesquiterpenoids were evaluated for their anti-inflammatory potential by applying the TPA-induced mouse ear edema model. The results revealed that some of these metabolites exhibit moderate anti-inflammatory activity. At a dose of 228 渭g/ear compound 1 showed 43.14 卤 8.09% inhibition on ear edema, indicating an IC₅₀ > 228 渭g/ear.