Enantiomerization Dynamics and a Catalytic Dynamic Resolution of N-Trimethylallyl-2-lithiopyrrolidine

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• 作者：Timothy K. Beng ; Taher I. Yousaf ; Iain Coldham ; Robert E. Gawley
• 刊名：Journal of the American Chemical Society
• 出版年：2009
• 出版时间：May 27, 2009
• 年：2009
• 卷：131
• 期：20
• 页码：6908-6909
• 全文大小：120K
• 年卷期：v.131,no.20(May 27, 2009)
• ISSN：1520-5126

文摘

The barriers to enantiomerization of N-trimethylallyl-2-lithiopyrrolidine have been measured in the presence of sparteine,1, N,N′-diisopropylbispidine, 2, and diaminoalkoxide 3. We have additionally demonstrated a rare example of a catalytic dynamic resolution using either of two ligands, achieving enantiomer ratios of up to 93:7.