Polyhalogenated Indoles from the Red Alga Rhodophyllis membranacea: The First Isolation of Bromo-Chloro-Iodo Secondary Metabolites
详细信息 查看全文
- 作者：Victoria H. Woolner ; Cori M. Jones ; Jessica J. Field ; Nazmi H. Fadzilah ; Andrew B. Munkacsi ; John H. Miller ; Robert A. Keyzers ; Peter T. Northcote
- 刊名：Journal of Natural Products
- 出版年：2016
- 出版时间：March 25, 2016
- 年：2016
- 卷：79
- 期：3
- 页码：463-469
- 全文大小：293K
- ISSN：1520-6025
文摘
An unusual tetrahalogenated indole with the exceptionally rare inclusion of the three halogens bromine, chlorine, and iodine was found using mass spectrometry within a fraction of a semipurified extract obtained from the red alga Rhodophyllis membranacea. We report herein the isolation and structure elucidation, using a combination of NMR spectroscopy and mass spectrometry, of 11 new tetrahalogenated indoles (1–11), including four bromochloroiodoindoles (5–7, 10). Several were evaluated for cytotoxic and antifungal activities against the HL-60 promyelocytic cell line and Saccharomyces cerevisiae, respectively.