Soudanones A鈥揋: Antifungal Isochromanones from the Ascomycetous Fungus Cadophora sp. Isolated from an Iron Mine

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• 作者：Yudi Rusman ; Benjamin W. Held ; Robert A. Blanchette ; Sergio Wittlin ; Christine E. Salomon
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：June 26, 2015
• 年：2015
• 卷：78
• 期：6
• 页码：1456-1460
• 全文大小：234K
• ISSN：1520-6025

文摘

One new isochromane (pseudoanguillosporin C, 2), seven isochromanones (soudanones A鈥揋, 3鈥?b>9), and six known analogues including 10 and 11 were isolated from a culture of the fungus Cadophora sp. 10-5-2 M, collected from the subterranean 10th level of the Soudan Underground Iron Mine in Minnesota. All of the compounds were tested against a panel of microbial pathogens, and 2, 3, 10, and 11 were found to have activity against Cryptococcus neoformans (MIC = 35, 40, 20, and 30 渭g/mL, respectively). Compound 11 was also active against Candida albicans, with an MIC of 40 渭g/mL.