Phosphonated Carbocyclic 2'-Oxa-3'-azanucleosides as New Antiretroviral Agents

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• 作者：Ugo Chiacchio ; Antonio Rescifina ; Daniela Iannazzo ; Anna Piperno ; Roberto Romeo ; Luisa Borrello ; Maria Teresa Sciortino ; Emanuela Balestrieri ; Beatrice Macchi ; Antonio Mastino ; Giovanni Romeo
• 刊名：Journal of Medicinal Chemistry
• 出版年：2007
• 出版时间：July 26, 2007
• 年：2007
• 卷：50
• 期：15
• 页码：3747 - 3750
• 全文大小：53K
• 年卷期：v.50,no.15(July 26, 2007)
• ISSN：1520-4804

文摘

Phosphonated carbocyclic 2'-oxa-3'-azanucleosides have been synthesized and tested for their antiretroviralactivity. The obtained results have shown that some of the compounds were as powerful as azydothymidinein inhibiting the reverse transcriptase activity of the human retrovirus T-cell leukemia/lymphotropic virustype 1 and in protecting human peripheral blood mononuclear cells against human retrovirus T-cell leukemia/lymphotropic virus type 1 transmission in vitro. These data indicate that phosphonated carbocyclic 2'-oxa-3'-azanucleosides possess the necessary requirements to efficiently counteract infections caused by humanretroviruses.