First Example of Direct RuO4-Catalyzed Oxidation of Isoxazolidines to 3-Isoxazolidones

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• 作者：Anna Piperno ; Ugo Chiacchio ; Daniela Iannazzo ; Salvatore V. Giofrè ; Giovanni Romeo ; Roberto Romeo
• 刊名：Journal of Organic Chemistry
• 出版年：2007
• 出版时间：May 11, 2007
• 年：2007
• 卷：72
• 期：10
• 页码：3958 - 3960
• 全文大小：66K
• 年卷期：v.72,no.10(May 11, 2007)
• ISSN：1520-6904

文摘

RuO₂/NaIO₄ oxidation of 3-unsubstituted isoxazolidines,under ethyl acetate/water biphasic conditions, affords 3-isoxazolidones in good yields. The methodology can be used onboth racemic and optically active isoxazolidines.