Characterization of l-Digitoxosyl-phenanthroviridin from Streptomyces venezuelae ISP5230

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• 作者：Andrew W. Robertson ; Camilo F. Martinez-Farina ; Raymond T. Syvitski ; David L. Jakeman
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：August 28, 2015
• 年：2015
• 卷：78
• 期：8
• 页码：1942-1948
• 全文大小：490K
• ISSN：1520-6025

文摘

The jadomycin-derived compound lass="smallcaps">l-digitoxosyl-phenanthroviridin was isolated from fermentations of Streptomyces venezuelae ISP5230 grown in nutrient-deficient media with lass="smallcaps">l-lysine as the sole nitrogen source. Structural elucidation was accomplished using a combination of high-resolution MS, LC-MS/MS, and 1D- and 2D-NMR. The compound was evaluated against the National Cancer Institute (NCI) 60 human tumor cell line screen in both the one-dose and five-dose screens, and cytotoxicity was compared to a small library of jadomycin analogues to probe the structure鈥揳ctivity relationship.