Particle Shape Characterisation via Image Analysis: from Laboratory Studies to In-process Measurements Using an in Situ Particle Viewer System
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- 作者：Rui Fa Li ; Radoslav Penchev ; Vasuki Ramachandran ; Kevin J. Roberts ; Xue Z. WangRichard J. Tweedie ; ; Andy PriorJan W. Gerritsen ; ; Fred M. Hugen
- 刊名：Organic Process Research & Development
- 出版年：2008
- 出版时间：September 19, 2008
- 年：2008
- 卷：12
- 期：5
- 页码：837-849
- 全文大小：703K
- 年卷期：v.12,no.5(September 19, 2008)
- ISSN：1520-586X
文摘
A recent evaluation of a new in situ particle viewer (ISPV) system for the examination of particle shape and its subsequent development during crystal growth is presented. Precharacterization studies using conventional and hot-stage microscopy reveal that the ISPV probe system together with a commercial image analysis software is capable of generating representative high-quality images which can be processed and analysed. ISPV studies of the batch crystallization of l-glutamic acid in a 20-L reactor are shown to be able to characterise effectively crystallization and polymorphic phase transformation processes, revealing potential applications in both small- and large-scale reactor systems. Some improvements to the probe, such as increasing the resolution and reducing the encrustation using thermal coating, are suggested.