Divergent Approach to a Family of Tyrosine-Derived Ru鈥揂lkylidene Olefin Metathesis Catalysts

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• 作者：Ellen C. Gleeson ; Zhen J. Wang ; W. Roy Jackson ; Andrea J. Robinson
• 刊名：Journal of Organic Chemistry
• 出版年：2015
• 出版时间：July 17, 2015
• 年：2015
• 卷：80
• 期：14
• 页码：7205-7211
• 全文大小：428K
• ISSN：1520-6904

文摘

A simple and generic approach to access a new family of Ru鈥揳lkylidene olefin metathesis catalysts with specialized properties is reported. This strategy utilizes a late stage, utilitarian Hoveyda-type ligand derived from tyrosine, which can be accessed via a multigram-scale synthesis. Further functionalization allows the catalyst properties to be tuned, giving access to modified second-generation Hoveyda鈥揋rubbs-type catalysts. This divergent synthetic approach can be used to access solid-supported catalysts and catalysts that function under solvent-free and aqueous conditions.