Synthesis of Novel and Uniquely Shaped 3-Azabicyclo[4.2.0]octan-4-one Derivatives by Sequential Ugi/[2+2] Ene-Enone Photocycloadditions

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• 作者：Irini Akritopoulou-Zanze ; Alan Whitehead ; Jan E. Waters ; Rodger F. Henry ; Stevan W. Djuric
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：March 29, 2007
• 年：2007
• 卷：9
• 期：7
• 页码：1299 - 1302
• 全文大小：98K
• 年卷期：v.9,no.7(March 29, 2007)
• ISSN：1523-7052

文摘

We report a new methodology for the construction of novel and uniquely shaped 3-azabicyclo[4.2.0]octan-4-one derivatives by combining theUgi multicomponent reaction with [2+2] enone-olefin photochemical transformations. The overall sequence is capable of creating up to fivestereocenters; however, in most cases, only two diastereomers are observed.