Organochlorine Compounds, Iodine Intake, and Thyroid Hormone Levels during Pregnancy

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• 作者：Mar Alvarez-Pedrerol ; Mnica Guxens ; Jess Ibarluzea ; Marisa Rebagliato ; gueda Rodriguez ; Mercedes Espada ; Fernando Goi ; Mikel Basterrechea ; Jordi Sunyer
• 刊名：Environmental Science & Technology
• 出版年：2009
• 出版时间：October 15, 2009
• 年：2009
• 卷：43
• 期：20
• 页码：7909-7915
• 全文大小：197K
• 年卷期：v.43,no.20(October 15, 2009)
• ISSN：1520-5851

文摘

The effect of organochlorine compounds (OCs) on thyroid function, as well as the potential confounding effect of iodine intake, was studied in a large sample of pregnant women from two population-based cohort studies in Sabadell (n = 520) and Gipuzkoa (n = 570), Spain. Thyroid hormones (free T4 and total T3), thyrotropin, and polychlorinated biphenyls (PCB congeners 118, 138, 153, and 180), hexachlorobenzene (HCB), beta-hexachlorocyclohexane (β-HCH), dichlorodiphenyl dichloroethylene (p′p′-DDE) and dichlorodiphenyl trichloroethane (p′p-DDT) were measured in serum samples collected at first trimester of pregnancy. Urinary iodine concentration (UIC) was measured and iodine intake from diet, iodized salt, and supplements were estimated from a food frequency questionnaire. Levels of HCB and PCBs congeners 180, 153, and 138 were related to lower total T3 levels (adjusted coefficient (SE): −4.0(1.1), −6.1(1.6), −5.5(1.6), and 3.8(1.4), respectively) and higher free T4 levels (adjusted coefficient (SE): 0.013(0.005), 0.017(0.007), 0.016(0.007), and 0.007(0.006), respectively). These associations were homogeneous in both cohorts, especially for PCBs and total T3 (p-value for the interaction between cohorts >0.8). Iodine intake and UIC did not affect the association between OCs and thyroid hormones. Our results indicate that exposure to OCs during pregnancy can alter TH levels.