The Aryne aza-Diels鈥揂lder Reaction: Flexible Syntheses of Isoquinolines

详细信息    查看全文

• 作者：Juan-Carlos Castillo ; Jairo Quiroga ; Rodrigo Abonia ; Jean Rodriguez ; Yoann Coquerel
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：July 2, 2015
• 年：2015
• 卷：17
• 期：13
• 页码：3374-3377
• 全文大小：380K
• ISSN：1523-7052

文摘

Two cascade reactions have been developed for the time-efficient preparation of a variety of functionalized aromatic heterocyclic products exhibiting an isoquinoline core. The approach is based on the normal electron-demand [4 + 2] aza-Diels鈥揂lder cycloaddition of electron-rich N-aryl imines with arynes. Using this strategy, an expeditious total synthesis of the naturally occurring benzo[c]phenanthridine alkaloid nornitidine was achieved.