Pseudo-Multicomponent Reactions of Arynes with N-Aryl Imines

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• 作者：Juan-Carlos Castillo ; Jairo Quiroga ; Rodrigo Abonia ; Jean Rodriguez ; Yoann Coquerel
• 刊名：Journal of Organic Chemistry
• 出版年：2015
• 出版时间：October 2, 2015
• 年：2015
• 卷：80
• 期：19
• 页码：9767-9773
• 全文大小：349K
• ISSN：1520-6904

文摘

Pseudo-three-component reactions are described for the conversion of simple N-aryl imines into 1,2-dihydroisoquinoline-type products. The approach relies on a regioselective cascade reaction involving two equivalents of the aryne component iteratively as a dienophile and as an electrophile. Some examples of related, more complex pseudo-four-component cascade processes are also reported.