Enantioselective Syntheses of Furan Atropisomers by an Oxidative Central-to-Axial Chirality Conversion Strategy
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- 作者：Vivek S. Raut ; Marion Jean ; Nicolas Vanthuyne ; Christian Roussel ; Thierry Constantieux ; Cyril Bressy ; Xavier Bugaut ; Damien BonneJean Rodriguez
- 刊名：Journal of the American Chemical Society
- 出版年：2017
- 出版时间：February 15, 2017
- 年：2017
- 卷：139
- 期：6
- 页码：2140-2143
- 全文大小：489K
- ISSN：1520-5126
文摘
For the first time, enantiomerically enriched atropoisomeric furans have been accessed using a central-to-axial chirality conversion strategy. Hence, oxidation of the enantioenriched dihydrofuran precursors gave rise to axially chiral furans with high enantiopurities accounting from excellent conversion percentages (cp) in most cases.