Synthesis and Structural Analysis of a New Class of Azaspiro[3.3]heptanes as Building Blocks for Medicinal Chemistry

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• 作者：Johannes A. Burkhard ; Carine Gurot ; Henner Knust ; Mark Rogers-Evans ; Erick M. Carreira
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：May 7, 2010
• 年：2010
• 卷：12
• 期：9
• 页码：1944-1947
• 全文大小：219K
• 年卷期：v.12,no.9(May 7, 2010)
• ISSN：1523-7052

文摘

Straightforward access toward previously unreported substituted, heterocyclic spiro[3.3]heptanes is disclosed. These spirocyclic systems may be considered as alternatives to 1,3-heteroatom-substituted cyclohexanes, which are otherwise insufficiently stable to allow their use in drug discovery. Conformational details are discussed on the basis of X-ray crystallographic structures.