Isolation of Cytotoxic Metabolites from Targeted Peruvian Amazonian Medicinal Plants
详细信息 查看全文
- 作者：José ; C. Aponte ; Abraham J. Vaisberg ; Rosario Rojas ; Luz Caviedes ; Walter H. Lewis ; Gerardo Lamas ; Cé ; sar Sarasara ; Robert H. Gilman ; Gerald B. Hammond
- 刊名：Journal of Natural Products
- 出版年：2008
- 出版时间：January 2008
- 年：2008
- 卷：71
- 期：1
- 页码：102 - 105
- 全文大小：77K
- 年卷期：v.71,no.1(January 2008)
- ISSN：1520-6025
文摘
The antiproliferative bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), nataloe-emodin (2), bisnordihydrotoxyferine (4), 2′,4′-dihydroxy-6′-methoxy-3,4-methylenedioxydihydrochalcone (5), and 2′,4′-dihydroxy-4,6′-dimethoxydihydrochalcone (6) and 12-O-tetradecanoylphorbol-13-acetate (7), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against Mycobacterium tuberculosis is also reported.