Analysis of Ochratoxin A in Foods Consumed by Inhabitants from an Area with Balkan Endemic Nephropathy: A 1 Month Follow-up Study

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• 作者：Terry Vrabcheva ; Theodora Petkova-Bocharova ; Frederic Grosso ; Ivan Nikolov ; Ivan Nicolaï ; Chernozemsky ; Marcel Castegnaro ; and Sylviane Dragacci
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2004
• 出版时间：April 21, 2004
• 年：2004
• 卷：52
• 期：8
• 页码：2404 - 2410
• 全文大小：58K
• 年卷期：v.52,no.8(April 21, 2004)
• ISSN：1520-5118

文摘

In the 1950s, a series of publications from Bulgaria, Yugoslavia, and Romania locally described akidney disease called Balkan Endemic Nephropathy (BEN). In Bulgaria, the exposure of populationsto ochratoxin A (OTA) was supported by analysis of individual food items demonstrating a higherprevalence and higher levels of OTA in food from the high-incidence areas of BEN. In this work, foodconsumption from a series of individuals from two villages of the BEN area during 1 month wasfollowed using the duplicate diet method. Meals consumed by volunteers from both villages showeduneven OTA contents, spreading from below the limit of quantification (<0.07 g/kg) to 2.6 g/kg.The average weekly intake of OTA varies from 1.86 to 92.7 ng/kg of body weight. Some of theselevels approach the provisional tolerable weekly intake (PTWI) established by the JECFA at 100ng/kg of body weight. These results confirm previous studies performed in the same area anddemonstrate the high exposure of this population to OTA, thus strengthening the hypothesis of theinvolvement of this mycotoxin in BEN etiology.Keywords: Ochratoxin A; Balkan Endemic Nephropathy (BEN); food contamination; dietary intake