Stereoselective Titanium-Mediated Aldol Reactions of a Chiral Lactate-Derived Ethyl Ketone with Ketones
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- 作者：Sandra Alcoberro ; Alejandro Gómez-Palomino ; Ricard Solà ; Pedro Romea ; Fèlix Urpí ; Mercè Font-Bardia
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：January 17, 2014
- 年：2014
- 卷：16
- 期：2
- 页码：584-587
- 全文大小：213K
- ISSN：1523-7052
文摘
Aldol reactions of titanium enolates of lactate-derived ethyl ketone 1 with other ketones proceed in a very efficient and stereocontrolled manner provided that a further equivalent of TiCl4 is added to the reacting mixture. The scope of these reactions encompasses simple ketones such as acetone or cyclohexanone as well as other ketones that contain potential chelating groups such as pyruvate esters or 伪- and 尾-hydroxy ketones.