Pulicatins A−E, Neuroactive Thiazoline Metabolites from Cone Snail-Associated Bacteria

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• 作者：Zhenjian Lin ; Rowena R. Antemano ; Ronald W. Hughen ; Ma. Diarey B. Tianero ; Olivier Peraud ; Margo G. Haygood ; Gisela P. Concepcion ; Baldomero M. Olivera ; Alan Light ; Eric W. Schmidt
• 刊名：Journal of Natural Products
• 出版年：2010
• 出版时间：November 29, 2010
• 年：2010
• 卷：73
• 期：11
• 页码：1922-1926
• 全文大小：166K
• 年卷期：v.73,no.11(November 29, 2010)
• ISSN：1520-6025

文摘

The cone snail Conus pulicarius from the Philippines provides a specific habitat for actinomycetes and other bacteria. A phenotypic screen using primary cultures of mouse dorsal root ganglion neurons revealed that one C. pulicarius associate, Streptomyces sp. CP32, produces a series of natural products that enhance or diminish whole-cell Ca²⁺ flux. These compounds include known thiazoline compounds and a series of new derivatives, pulicatins A−E (6−10). Individual compounds were shown to bind to a series of human receptors, with selective binding to the human serotonin 5-HT_2B receptor. Here, we report the structure elucidation of the new compounds and results of the neurological assays.