Tyrosyl-DNA Phosphodiesterase I Inhibitors from the Australian Plant Macropteranthes leichhardtii

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• 作者：Li-Wen Tian ; Yunjiang Feng ; Trong D. Tran ; Yoko Shimizu ; Tom Pfeifer ; Paul I. Forster ; Ronald J. Quinn
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：July 24, 2015
• 年：2015
• 卷：78
• 期：7
• 页码：1756-1760
• 全文大小：252K
• ISSN：1520-6025

文摘

Mass-directed isolation of the CH₂Cl₂/MeOH extract from the bark of an Australian plant, Macropteranthes leichhardtii, resulted in the purification of a new phenylpropanoid glucoside, macropteranthol (1), together with four known analogues (2鈥?b>5). The structure of compound 1 was elucidated by NMR and MS data analyses and quantum chemical calculations. Compounds 3 and 5 showed inhibitory activity against tyrosyl-DNA phosphodiesterase I with IC₅₀ values of 鈭?.0 渭M.