Fumonisin Disruption of Ceramide Biosynthesis in Maize Roots and the Effects on Plant Development and Fusarium verticillioides-Induced Seedling Disease

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• 作者：Lonnie D. Williams ; Anthony E. Glenn ; Anne Marie Zimeri ; Charles W. Bacon ; Mary Alice Smith ; Ronald T. Riley
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2007
• 出版时间：April 18, 2007
• 年：2007
• 卷：55
• 期：8
• 页码：2937 - 2946
• 全文大小：330K
• 年卷期：v.55,no.8(April 18, 2007)
• ISSN：1520-5118

文摘

The fungus Fusarium verticillioides infects maize and produces fumonisins, inhibitors of ceramidesynthase. Seeds of the cultivar Silver Queen were inoculated with fumonisin-producing or non-fumonisin-producing strains of F. verticillioides. Leaf lesion incidence and severity of effects on rootand stalk growth were significantly correlated with fumonisin in roots and disruption of sphingolipidmetabolism in roots. Uninoculated seeds grown in soil watered with solutions of fumonisin B₁ exhibitedabove-ground symptoms indicative of F. verticillioides-induced seedling disease and dose-dependentreduction in root mass that was inversely correlated with fumonisin B₁, sphingoid bases, and sphingoidbase 1-phosphates in roots. There was also evidence of an adaptive response to disrupted sphingolipidmetabolism in both the virulence and watering assays, suggesting induction of pathways responsiblefor metabolism of sphingoid base 1-phosphates after prolonged exposure. The results suggest thatfumonisin, and its effects on sphingolipids, could contribute to all aspects of F. verticillioides maizeseedling disease.