Hydrostable and Nitryl/Methyl-Functionalized Metal鈥揙rganic Framework for Drug Delivery and Highly Selective CO2 Adsorption

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• 作者：De-Yun Ma ; Zhi Li ; Jun-Xia Xiao ; Rong Deng ; Pei-Feng Lin ; Rui-Qun Chen ; Yun-Qiu Liang ; Hai-Fu Guo ; Bei Liu ; Jian-Qiang Liu
• 刊名：Inorganic Chemistry
• 出版年：2015
• 出版时间：July 20, 2015
• 年：2015
• 卷：54
• 期：14
• 页码：6719-6726
• 全文大小：510K
• ISSN：1520-510X

文摘

By using a strategy of introducing hydrophobic groups to the linkers, a hydrostable MOF was constructed based on 5-nitroisophthalate and 2,2鈥?dimethyl-4,4鈥?bipyridine coligands, revealing a 3D dia topology structure with a 1D channel parallel to the c axis. TGA, PXRD, and water vapor sorption results show high thermal and water stability for the framework. The framework is very porous and possesses not only high busulfan payloads with an encapsulation efficiency up to 21.5% (17.2 wt %) but also very high CO₂ selective capture compared with that of other small gases (i.e., CH₄, N₂, O₂, CO, and H₂) at 298 K based on molecular simulations due to the pore surface being populated by methyl and nitryl groups. Furthermore, in vitro MTT assays were conducted on four different cells lines with increasing concentrations of the framework, and the results showed that the framework was nontoxic (cell viability >80%) in spite of the concentrations up to 500 渭g/mL.