Nonhomogeneous Silica Promotes the Biologically Induced Delivery of Metal Ions from Silica-Coated Magnetic Nanoparticles

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• 作者：Ana B. D谩vila-Ib谩帽ez ; Rosal铆a Mari帽o-Fern谩ndez ; Melodie Maceira-Campos ; Andr茅s Garc铆a-Lorenzo ; Vicenta Mart铆nez-Zorzano ; Ver贸nica Salgueiri帽o
• 刊名：Journal of Physical Chemistry C
• 出版年：2014
• 出版时间：December 4, 2014
• 年：2014
• 卷：118
• 期：48
• 页码：28266-28273
• 全文大小：381K
• ISSN：1932-7455

文摘

Herein we report the endocytosis of magnetic nanoparticles of two different transition metal ferrites, which are coated with silica. The variation in the cytotoxicity results, which correlate with the metal ions from the magnetic cores, stems from the inhomogeneity of the silica shell and consequent partial degradation of the nanoparticles once loaded into the endosomes of Caco-2 cells.