Biologically Active Natural Products from Mongolian Medicinal Plants Scorzonera divaricata and Scorzonera pseudodivaricata

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• 作者：Nanzad Tsevegsuren ; RuAngelie Edrada ; Wenhan Lin ; Rainer Ebel ; Claudia Torre ; Sofia Ortlepp ; Victor Wray ; Peter Proksch
• 刊名：Journal of Natural Products
• 出版年：2007
• 出版时间：June 2007
• 年：2007
• 卷：70
• 期：6
• 页码：962 - 967
• 全文大小：110K
• 年卷期：v.70,no.6(June 2007)
• ISSN：1520-6025

文摘

Chromatographic separation of a crude extract obtained from the aerial parts of the Mongolian medicinal plant Scorzoneradivaricata yielded the two new quinic acid derivatives feruloylpodospermic acids A and B. Both compounds feature aferuloyl group and two dihydrocaffeoyl substituents. For feruloylpodospermic acid A, the dihydrocaffeic acid substituentswere found esterified at positions 1 and 5 of the quinic acid moiety, while the feruloyl group was attached at position3. For feruloylpodospermic acid B, the substituents were linked at positions 1, 3, and 4. The aerial parts of S.pseudodivaricata that are likewise used in Mongolian traditional medicine yielded two further new natural products,for which the names scorzoneric acid and scorzonerin are proposed. Scorzoneric acid is an unusual phenolic compoundfeaturing a central tetrasubstituted phenyl ring to which a glucose unit is bound, which in turn is substituted by anesterified acyl side chain. Further substituents of the central phenyl ring system include a butan-2-one group, which islinked to a second para-substituted phenyl ring system. Scorzonerin is a matricarin-based sesquiterpene lactone thatcarries an esterified dihydrocoumaric acid moiety, which in turn is glycosidically bound to glucose. The structures ofall new compounds were unambiguously established from NMR (¹H, ¹³C, COSY, HMBC) spectroscopic and massspectrometric data. The new quinic acid derivatives feruloylpodospermic acids A and B exhibited strong antioxidativeactivity when analyzed in the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay.