Could Killing Bacterial Subpopulations Hit Tuberculosis out of the Park?

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• 作者：Catherine Baranowski ; Eric J. Rubin
• 刊名：Journal of Medicinal Chemistry
• 出版年：2016
• 出版时间：July 14, 2016
• 年：2016
• 卷：59
• 期：13
• 页码：6025-6026
• 全文大小：139K
• 年卷期：0
• ISSN：1520-4804

文摘

One hurdle to treating tuberculosis could be that it is so difficult to kill nonreplicating subpopulations of the causative pathogens. This work describes two new cephalosporin derivatives that specifically target this population of Mycobacterium tuberculosis.