Jacaranone-Derived Glucosidic Esters from Jacaranda glabra and Their Activity against Plasmodium falciparum

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• 作者：M. Salom Gachet ; Olaf Kunert ; Marcel Kaiser ; Reto Brun ; Ricardo A. Muoz ; Rudolf Bauer ; Wolfgang Schhly
• 刊名：Journal of Natural Products
• 出版年：2010
• 出版时间：April 23, 2010
• 年：2010
• 卷：73
• 期：4
• 页码：553-556
• 全文大小：127K
• 年卷期：v.73,no.4(April 23, 2010)
• ISSN：1520-6025

文摘

In a survey of plants from Ecuador with antiprotozoal activity, Jacaranda glabra was found to show promising activity against the Plasmodium falciparum K1 strain. Subsequently, activity-guided isolation of the dichloromethane extract from the leaves of J. glabra afforded four new phenylethanoid glucosides containing jacaranone-type moieties (1−4), named jacaglabrosides A−D. Their chemical structures were identified using NMR spectroscopy and MS techniques. The compounds were found to be active in vitro against the P. falciparum K1 strain (IC₅₀ 1, 1.02; 2, 0.56; 3, 0.56; and 4, 0.55 μg/mL) and generally possessed a low cytotoxicity toward L-6 cells, with the exception of compound 1 (IC₅₀ 1, 8.3; 2, >90; 3, 87; and 4, 85 μg/mL).