Pd(II)-Catalyzed Ortho Arylation of 6-Arylpurines with Aryl Iodides via Purine-Directed C鈭扝 Activation: A New Strategy for Modification of 6-Arylpurine Derivatives

详细信息    查看全文

• 作者：Hai-Ming Guo ; Li-Li Jiang ; Hong-Ying Niu ; Wei-Hao Rao ; Lei Liang ; Run-Ze Mao ; De-Yang Li ; Gui-Rong Qu
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：April 15, 2011
• 年：2011
• 卷：13
• 期：8
• 页码：2008-2011
• 全文大小：749K
• 年卷期：v.13,no.8(April 15, 2011)
• ISSN：1523-7052

文摘

Purine is utilized as a new directing group for the Pd-catalyzed monoarylation of 6-arylpurines with simple aryl iodides via C鈭扝 bond activation in good yields, providing a complementary tool for the modification of 6-arylpurines (nucleosides). Most importantly, purine can be used as a building block for nucleoside derivatives, and the use of purine as a directing group helps avoid additional synthetic steps.